The Vatican City area consists mostly of the Vatican City and Castel St. Angelo. The place to search

The Vatican City area consists mostly of the Vatican City and Castel St. Angelo. The place to search for Rome vacation rentals and hotels near the Vatican would be upstream of the Vatican and Castel St Angelo, basically heading away from central Rome.
The Vatican area may not be as pedestrian friendly as perhaps the Campo de Fiori or Navona areas , with few green areas or roads closed to traffic, but it has its own charms. The nicest area to stroll around in is the park that encircles Castel Sant' Angelo . There is also a market between the Tevere (Tiber river) and Castel' Sant Angelo and usually some sort of activities (outdoor ice-skating, music and dancing etc.)
On the plus side - there are numerous commercial los angeles county registrar recorder outlets and opportunities to shop. Staying here has the benefit of close proximity to the Vatican City, Castel St. Angelo and the three Metro stops (see the map above).
All take you across the Tevere towards Piazza del Popolo and then Piazza los angeles county registrar recorder di Spagna and Termini Station (The main station). For more information about the Metro and the location of the stops see my dedicated page on the Rome Metro .
Rome tourist buses : Most of the Rome tourist buses have a stop in front of St Peter's square on Via della Conciliazione. los angeles county registrar recorder Why not hop on there, the Rome tourist buses are a great introduction to the city. They allow you to get your bearings, highlight the tourist attractions that interest you (I suggest you plan this, if you stop off at the first point of interest you may later get overwhelmed), and then select the ones that most interest you on your next lap around.
If you haven't read about it on my site already then ATAC public transportation in Rome site has a great tool to calculate the quickest route from point A to point B anywhere los angeles county registrar recorder in Rome (using public transport). When you arrive at the website click on the English language option to the right. Fill in your departure address and arrival address.