There are some off-airport agencies, but IIRC none of the majors, except for small neighborhood bran

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Our plan is to rent a car in Seattle and then visit Vancouver Island, Sunshine Hwy, Whistler. My questions are 1) I've read that Seattle really taxes rental cars picked up at SeaTac, so what are my options for convenient off airport car rental companies?
There are some off-airport agencies, but IIRC none of the majors, except for small neighborhood branches in nearby towns like Des Moines or Burien. I suspect your best bet is to head downtown and rent from one of the majors' downtown branches. You could take the light rail from the airport into the city for $2.75, or, assuming you're going to have the car for at least a week or so, a taxi to a downtown car agency would probably cost half of what you'd save in the rental cost, so you'd still be ahead. However I'd definitely do some online price comparisons; the prices will vary considerably depending on when you're renting, cheap tickets for airfare length of rental, etc. You might get lucky with an onsite rental, which would be far less hassle cheap tickets for airfare than the light rail or cab, etc.