My question to you knowledgeable Fodorites is, do you have any advise on best arrival airport given

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Hello there! We are 3 couples (55+) that are very excited to be planning a wonderful trip that will be taking us to Northern Italy, Southern France, and Northern casino hotels in reno Spain (Catalonia) next Sept.2014. The initial planning stages casino hotels in reno are always challenging for me, as so many variables come into play i.e. booking flights, booking cars, and just researching the different areas etc., etc., that I start to get the shakes!
This is a rough outline:Would like to make our way to Italy where we would like to visit Cinque casino hotels in reno a Terre, Genoa, and the Cuneo (Piedmonte) region. We are giving that area 1 week, if that makes sense, then on to stay in Uzes, France for a week (which I'm familiar with), before leaving for Barcelona and spending casino hotels in reno a week there.
Our travel casino hotels in reno style is casual, and we like to cook in our villa's in the evening, but really like the option of staying where there are options to shop and dine out. A little hustle casino hotels in reno and bustle works for us. We also like to be on our own schedule and so the rental casino hotels in reno van works for us. (We have traveled to the AC, Tuscany region, and the surrounding area, so we are used to the roads and a larger vehicle.
My question to you knowledgeable Fodorites is, do you have any advise on best arrival airport given the itinerary, rental car company, and/or doing a loop in and out of a more central airport as in Marseilles or Montpelier?
The way to save on a vehicle is to do a lease buy-back program casino hotels in reno (has to be at least 17 days). There are several different lease programs, but require pick up at major airports (possibly only Milan and Rome in Italy). This helps avoid the expensive casino hotels in reno drop off fee in another country and the lease rate is usually cheaper casino hotels in reno than just renting for the same amount of time.
I think I would fly to Nice, rent a French car (or two), visit your places in Italy, then Uzes, then on to Spain, fly home from Barcelona. All by car(s). It will involve a car drop-off charge, but for a party of 6 it would be a whole lot less expensive less hassle than flying within Europe.
Or course you realize that picking up a car in Italy requires that you also purchase CDW insurance (Italian law). Not so in France - your credit card company should be able to provide CDW. Many moons ago I checked with my CC company and they said that I would be covered by their CDW if I rented a car in France and drove it into Italy (and had an accident). However, check with your CC company to verify this.
Six people in a van driving some mountain roads (Alps) even some places around the CT, Provence, Cuneo would be troublesome for me - for many reasons. When we've traveled with close friends, we've always rented multiple cars so if we wanted to set off in different direction casino hotels in reno or have different plans for the day - we could do so.
Thanks kybourbon and StuDudley for your helpful advice. Really appreciate this. Yes, DH and I have been sitting here talking about the 2 cars and have decided that would be best for this trip. Yes, given the terrain and the availability casino hotels in reno all roads are leading to two vehicles. Thanks for the advice on the car rental idea, kybourbon...I'll be checking this out.
One more thing...would you get accommodation booked for the villas, as the ones we are looking casino hotels in reno at could get taken fast at that time of year? The flights from Toronto are not listed for this far out, but I would be afraid of losing out...
We are staying in 4 different "villas" in 2014, and we have already booked them. For our June trip, we booked the place in Nice and also in the Luberon (Provence) about 6-7 months ago. For Sept, the one on the Atlantic about 4 months ago, and the one in the Loire just yesterday.